One of the biggest bands of their time's guitarist used one of the most simplest set-ups; that title goes to Angus Young of AC/DC.
Angus is best known for his schoolboy outfit, dance moves (Duck walk that looks very similar to Chuck Berry's moves), and of course his SG electric guitar. It seems everything he has to create tone is on the minimal side of things.
Here a sample of his sound:
Here is his setup:
Guitar: 1964 Gibson SG Standard Electric Guitar
Amp: Marshall JMP 100 Watt MAster Volume Head
Cabinets: Marshall 1960A Slant Cabinet / 4x12, Marshall 1960B Straight Cabinet / 4x12
That's it. He plugs directly into his amp.
Hope you enjoy. Rock.